TRAZODONE
It is not a tricyclic compound; a highly selective but relatively less potent 5-HT uptake inhibitor; has weak anticholinergic action and low propensity to cause cardiac arrhythmias-may be peferred in elderly and glaucomatous patients. Inappropriate, prolonged and painful penile erection and impotence has been reported. Its sedative property is useful against concomitant anxiety & is less likely to cause convulsions or cardiotoxicity in overdose.Depression, depression associated with anxiety & insomnia, pseudodementia of depression origin, secondary depression in schizophrenia, depression in chronic alcoholism. Obsessive compulsive neurosis & phobic states are also improved.
50-200 mg/day. Initially 50 mg at bed time for first 3 days. Then increase to 100 mg at bed time, if well tolerated, give additional 50 mg in div. doses during day time.Usual total daily dose:3 mg/kg bodywt.
Breast feeding, pregnancy.
Concomitant use of C.N.S. depressants, alcohol & muscle relaxants. Hepatic or renal impairment. Epilepsy.Cardiovascular disorders.Prolonged & painful penile erection & impotence. Paediatrics: Safety not established. Pregnancy & Lactation:Unsafe. Elderly: Dose should be reduced.
Headache, drowsiness, dizziess.
Increases serum digoxin and phenytoin levels, sedative effect enhanced by alcohol and other CNS depressants, MAOIs should not be given within 1 weak of discontinuing trazodone.
