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Valganciclovir is an anti-viral drug, dosing, indications, interactions

Look for Drugs and Conditions

VALGANCICLOVIR

VALGANCICLOVIR

Valganciclovir is an antiviral medication used primarily to treat and prevent infections caused by cytomegalovirus (CMV) in patients with compromised immune systems, such as those undergoing organ transplants or with HIV/AIDS. It is a prodrug that is rapidly converted into its active form, ganciclovir, in the body.

Indications

For treatment for CMV retinitis in HIV patient, for prevention of CMV disease in patient with heart, kidney, or kidney-pancreas transplant.


Dosage

-Dosage can vary based on the specific indication and the patient's renal function. -Typically, the recommended dose for treating CMV retinitis in adults is 900 mg twice daily for 21 days, followed by 900 mg once daily for maintenance. -For preventing CMV disease in transplant recipients, the recommended dose is 900 mg once daily, starting within 10 days of transplantation and continuing for 100 days (200 days in some cases). -Dose adjustments may be necessary based on renal function.


Contra-Indications

hypersensitivity reaction to valganciclovir, ganciclovir


Special Precautions

Paediatric: Safety and efficacy not established in congenital CMV Pregnancy: Category C Lactation: Safety not yet established Elderly: safety and efficacy above 65 years not yet established


Side Effects

(Severe) neutropenia, anaemia, Dyspnoea, Diarrhoea, Oral candidiasis, sepsis (bacteraemia, viraemia), cellulitis, urinary tract infection, Decreased appetite, anorexia, Depression, anxiety, confusion, abnormal thinking, Headache, insomnia, dysgeusia, (taste disturbance), Ear pain, Cough, Nausea, vomiting, abdominal pain, upper abdominal pain, dyspepsia, constipation, flatulence, dysphagia


Drug Interactions

Imipenem-cilastatin. Probenecid, Trimethoprim, Mycophenolate Mofetil, Stavudine, Zidovudine, Didanosine


Other Brands With Same Generic
Brand Name Manufactured by
CELVIR CALREN CARE LIFESCIENCES
CMVCEL CELERA PHARMA PVT.LTD

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