Inducing remission in childhood acute leukemia, lymphosarcoma. Hodgkin’s disease, Wilm’s tumour. Ewing’s sarcoma and carcinoma lung.
Children : 2mg/sq.m. body surface. Adults: 1.4 mg/sq.m. body surface.
Acute uric acid neuropathy may occur. Reduce bone marrow reserve, impaired liver function, bronchospasm and jaundice. Paediatrics: Adjust dose according to body weight. Pregnancy: Should not be used. Lactation: Use with caution. Elderly: Use with caution.
Peripheral neuropathy, alopecia, Bone marrow depression.
Potentiation of other myelosuppressive drugs. Acute bronchospasm with mitomycin C. May decrease digoxin serum levels. Synergistic with methotrexate.