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5-Fluorouracil- Drug Interactions, Dosage, Side Effects, indications, Uses and Precautions

Look for Drugs and Conditions

5-FLUOROURACIL

5-FLUOROURACIL

It is pyrimidine analogue and is converted in the body to the corresponding 5 fluoro-2-deoxyuridine monophosphate, which inhibits thymidylate synthetase and blocks the conversion of deoxyuridilic acid to deoxythymidylic acid. Selective failure of DNA synthesis occurs due to non-availability of thymidylate: thymidine can partially reverse its toxicity.

Indications

Malignant neoplasms of breast, colon, urinary bladder, liver, pancreas, adjuvant to surgery, radiotherapy & other chemotherapeutic drugs. Topical application in cutaneous basal cell carcinoma.


Dosage

12 mg/kg body wt once daily for 4 successive days i.v. Max daily dose: 800 mg.


Contra-Indications

pregnancy. Depresed bone marrow function. Serious infections. Poor nutritional state.


Special Precautions

Careful care at some Hospital or nursing home must for 1st course of treatment. Paediatrics: Should not be used. Pregnancy: Should not be used. Lactation: Should not be used. Elderly: May increase the adverse effects.


Side Effects

Toxicity on bone marrow & G.I.T. Nausea, vomiting, Skin pigmentation.


Drug Interactions

Leucovorin calcium enhances the toxicity of fluorouracil.


Other Brands With Same Generic
Brand Name Manufactured by
FLUDIN BIOLOGICAL- E LTD
NEOFLUR CIPLA
ONCOURCIL TIMES DRUGS & PHARMACEUTICALS (P) LTD.

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