Asenapine Maleate

Asenapine is atypical antipsychotic with high affinity and potency for blocking dopamine, serotonin, a-adrenergic and histamine receptors, and no appreciable activity at muscarinic cholinergic receptors. The mechanism of action of asenapine, like other atypical antipsychotics is believed to be mediated through a combination of antagonist activity at 5-HT2A and D2 receptors.

Indications

Schizophrenia, Maniac episode of Bipolar disorder

Dosage

Oral; 5-10 mg twice daily

Contra-Indications

Hypersensitivity

Special Precautions

Increased Mortality in Geriatric Patients with Dementia-related Psychosis Paediatric: Not known if safe for creted into milk Elderly : Risk of poor tolerance and orthostasis, increased risk of adverse cardiovascular events.

Side Effects

allergic reaction, somnolence (including sedation and hypersomnia),dizziness, extrapyramidal symptoms other than akathisia (e.g., dystonia, blepharospasm, torticollis, dyskinesia, tardive dyskinesia, muscle rigidity, parkinsonism, gait disturbance, masked facies, tremor), weight gain.