LOVASTATIN
It is absorbed from GIT. It undergoes extensive first pass metabolism in liver which is the primary site of action. It is highly bound to plasma protein. Absorption is reduced by approximately 30% when administered on an empty stomach ther than with food. Lovastatin is eliminted primarily through fecal route which is the 83% of orally administered dose, 10% of drug is eliminated by renal route.As an adjunct to diet for the reduction of elevated total & LDL cholesterol in patients of primary hypercholesterolemia, for reduction of elevated LDL cholesterol levels in patients with combined hypercholesterolemia and hypertriglyceridemia.
10-80 mg/day in single or divided doses.
Hypersensitivity, Active liver disease or unexplained persistent elevations of serum transaminases, pregnancy & nursing.
Pregnancy & Lactation.
Flatulence, diarrhoea, constipation, nausea, abdominal pain, cramps, dyspepsia, heart burn, dysgeusia, myopathy, myalgia, rhabdomyolysis, blurred vision, headache, dizziness, rashes, impotene, insomnia.
Anticoagulants, coumarin-or indandione derivative, HMG-COA reductase inhibitors, cyclosporine erythromycin, Gemfibrozil, immunosuppresants or niacin.