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Carbidopa and Benserazide

Carbidopa and Benserazide

They are extra-cerebral dopa-decarboxylase inhibitors; they onot penetrate blood brain barrier and donot inhibit conversion of levodopa to Dopamine in brain. Administered along with levodopa, they increase its t1/2 in the periphery and make more of it available to cross blood brain barrier to reach its site of action. Benefits thus obtained are : a) Dose of levodopa is reduced to 1/4. b) Therapeutic doses of levodopa can be attained quickly. c)Cardiac complication are reduced.

Indications

Parkinson’s disease and syndrome, patients not responding adequately to levodopa alone.


Contra-Indications

Same as that for Levodopa.


Special Precautions

Same as that for Levodopa.


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