DEGARELIX

It is GnRH antagonist, which causes minimal histamine release, used for prostate cancer.

Indications

Advanced prostate cancer.

Dosage

Subcutaneous; given in abdomen region, starting dose is 240mg in two doses, while maintenance dose is 80mg administered every 28 days.

Contra-Indications

Known hypersensitivity to degarelix, pregnancy.

Special Precautions

Paediatric: Safety and effectiveness in paediatric group not yet established. Pregnancy: Contraindicated. Lactation: Not known if excereted in milk. Elderly: Increase sensitivity, use with caution.

Side Effects

Pain, erythema , swelling, induration  and nodule at the site , weight increase, fatigue, chills, hot flushes, increased liver enzymes, hypertension, arthralgia.

Drug Interactions

Data not sufficient.