GRANISETRON
Same as Ondansetron.Nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy.
Parenteral : Adult: 10mcg/kg intravenously within 30 minutes before initiation of chemotherapy. This should be given only on the days of chemotherapy. Children: 2-16 yrs of age : 10mcg/kg. Oral: Adult: 2mg once daily (upto 1 hour before chemotherapy) or 1mg twice daily (first 1mg to be given upto one hour before chemotherapy and the second 1mg tablet to be given 12 hrs. after the first dose) The drug is to be administered only on the days of chemotherapy. Children: Not recommended.
Hypersensitivity. Children below 2 years.
Anxiety, fever, headache, asthenia, somnolence, dizziness, insomnia. Elevation of liver enzymes (AST & ALT).
Inducers or inhibitors of hepatic Cytochrome P450 drug metabolising enzymes: Granisetron does not induce or inhibit the cytochrome P450 drug metabolising enzyme system.
